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Fritz said:
Care should be taken if adrenaline is given with Propranolol, as this combination can cause severely high blood pressure and heart failure. Propranolol may increase oxygen requirements by increasing left ventricular fiber length, end diastolic pressure, and systolic ejection period. Propranolol reduces the workload of the heart and so decreases its demand for oxygen. Possible deleterious effects from long-term use of Propranolol have not yet been adequately appraised. The gastrointestinal tract and undergoes extensive presystemic elimination due to its high hepatic clearance. Propranolol exerts ant arrhythmic effects in concentrations producing beta-adrenergic blockade, which appears to be its principal ant arrhythmic mechanism of action. Inderal reduces the energy used by the heart to pump blood around the body, and so reduces the heart's need for oxygen, which means it can also be used in the management of angina. Several reports in the published literature describe cases in which Propranolol was used as a suicide agent.
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